St. Mary's is one of two Catholic Primary schools in the parish of Ascot Vale. Its sister school is St. Margaret's, Maribyrnong.
The area of the parish allocated to St. Mary’s School is bounded by Ascot Vale Rd. to the east, Flemington Racecourse to the south, the Maribyrnong River to the west and Holmes Rd. to the north and the railway line to the northeast. The school property is bounded by Roseberry St. (the postal address and main entrance), Ferguson St. and St. Leonard’s Rd.
St Mary’s is in close proximity to many services and facilities. It is within walking distance of the Royal Agricultural Showgrounds, the Ascot Vale Public Library, two shopping centres, and sporting and recreation facilities such as Walter St. Reserve, Maribyrnong Park, Aberfeldie Park, Ascot Vale Leisure Centre and Riverside Golf and Tennis Centre.
St. Mary’s is well-serviced by public transport, namely trams, trains and buses, enabling easy access to other facilities.
There are four childcare centres and two kindergartens in the locality. As well, there is St. Margaret’s Primary School, two Government Primary schools, several private and Government Secondary colleges, a Language Centre and a Special Developmental School, that are easily accessible.
In recent years the area has seen the redevelopment of large residential blocks into high-density, multiple-dwelling sites.
The parish of Ascot Vale is in a stage of regrowth, with many new families with young children moving into the area. Hence a major goal in the parish is to develop a sense of community in all aspects of parish life. The school is supportive of this.